Featured Publications

Seroprevalence, risk factor, and spatial analysis of Zika virus infection after the 2016 epidemic in Managua, Nicaragua. 
Zambrana, J.V., Bustos, F., Burger-Calderon, R., Collado, D., Jairo, Sanchez, N., Ojeda, S., Plazaola, M., Lopez, B., Arguello, S., Elizondo, D., Aviles, W., Kuan, G., Balmaseda, A., Gordon, A., Harris, E. (2018)
Proc. Natl. Acad. Sci. USA. 2018 Sep 11;115(37):9294-9299. doi: 10.1073/pnas.1804672115. Epub 2018 Aug 27.

Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases.
Michlmayr D., Pak T.R., Rahman A.H., Amir E.D., Kim E.Y., Kim-Schulze S., Suprun M., Stewart M.G., Thomas G.P., Balmaseda A., Wang L., Zhu J., Suaréz-Fariñas M., Wolinsky S.M., Kasarskis A., Harris E. (2018)
Mol. Syst. Biol. 2018 Aug 27;14(8):e7862. doi: 10.15252/msb.20177862.

Differences in transmission and disease severity between two successive waves of chikungunya.
Gordon, A., Gresh, L., Ojeda, S., Chowell-Puente, G., Gonzalez, K., Sanchez, N., Saborio, S., Mercado, J.C., Kuan, G., Balmaseda, A., and Harris, E. (2018)
Clin. Infect. Dis. 2018 Apr 25. doi: 10.1093/cid/ciy356. [Epub ahead of print].

Antibody-dependent enhancement of severe dengue disease in humans.
Katzelnick., L. Gresh, L, Halloran, M.E., Mercado, J.C., Kuan, G., Gordon, A., Balmaseda, A., and Harris, E. (2017)
Science. 358(6365):929-932.

Longitudinal analysis of antibody cross-neutralization following Zika and dengue virus infection in Asia and the Americas
Montoya, M., Collins, M., Dejnirattisai, W., Katzelnick, L.C., Puerta-Guardo, H., Jadi, R., Schildhauer, S., Supasa, P., Vasanawathana, S., Malasit, P., Mongkolsapaya, J., de Silva, A.D., Tissera, H., Balmaseda, A., Screaton, G., de Silva, A.M., Harris, E. (2018)
J. Infect. Dis. 218(4):536-545.

CD14+ CD16+ monocytes are the main targets of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua.
Michlmayr, D., Andrade, P., Gonzalez, K., Balmaseda, A., and Harris E. (2017)
Nat Microbiol. 2(11):1462-1470. 2017.

Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx integrity. 
Glasner, D.R., Ratnasiri, K., Puerta-Guardo, H., Beatty, P.R., and Harris, E. (2017)
PLoS Pathog. 13(11):e1006673.

Analysis of individuals from a dengue-endemic region helps define the footprint and repertoire of antibodies targeting dengue virus 3 type-specific epitopes.
Andrade, D.V., Katzelnick, L.C., Widman, D.G., Balmaseda, A., de Silva A.M., Baric, R.S., and Harris, E. (2017)
mBio. 8(5):e01205-17.

Intrahost selection pressures drive rapid dengue virus microevolution in acute human infections.
Parameswaran, P., Wang, C., Trivedi, S.B., Eswarappa, M., Montoya, M., Balmaseda, A., and Harris, E. (2017)  
Cell Host Microbe. 22(3):400-410.e5.

Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. 
Tabata, T., Petitt, M., Puerta-Guardo, H., Michlmayr, D., Wang, C., Fang-Hoover, J., Harris, E.* and Pereira, L.* (2016)
Cell Host Microbe. In press (Epub July 18, 2016) S1931-3128(16)30300-6. doi: 10.1016/j.chom.2016.07.002. *Co-corresponding authors. 

Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability. 
Puerta-Guardo, H., Glasner, D.R., and Harris, E. (2016)
PLoS Pathog.12(7):e1005738.

Dengue virus non-structural protein 1 (NS1) triggers vascular leak that can be inhibited by anti-NS1 antibodies. 
Beatty, P.R., Puerta Guardo, H., Killingbeck, S., Glasner, D., Hopkins, K., and Harris, E. (2015)
Sci Transl Med. 7:304ra141.

Evidence based community mobilization for dengue prevention in Nicaragua and Mexico (Camino Verde, the Green Way): cluster randomized controlled trial.
Andersson, N., Nava-Aguilera, E., Arostegui, J., Morales-Perez, A., Suazo-Laguna, H., Legorreta-Soberanis, J., Hernandez-Alvarez, C., Fernandez-Salas, I., Balmaseda, A., Cortés-Guzmán, A.J., Coloma, J., Ledogar, R.J., and Harris, E. (2015)  
BMJ. 351:h3267.